The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

CYP2D8P  -  cytochrome P450, family 2, subfamily D,...

Homo sapiens

Synonyms: CYP2D8P1, CYP2DP1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on CYP2D8P1

  • A pseudogene CYP2D8P and a related gene CYP2D7 are located upstream from CYP2D6 [1].
  • CYP2D8P contains several gene-disrupting insertions, deletions, and termination codons within its exons, indicating that this is a pseudogene [2].
  • CYP2D7, which is just downstream of CYP2D8P, is apparently normal, except for the presence, in the first exon, of an insertion that disrupts the reading frame [2].
 

Analytical, diagnostic and therapeutic context of CYP2D8P1

  • A single set of PCR and sequencing primers was used to coamplify and sequence a region in the CYP2D6 gene and the equivalent region in the CYP2D8P pseudogene, and relative quantification between these fragments was performed [3].

References

  1. Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Gaedigk, A., Blum, M., Gaedigk, R., Eichelbaum, M., Meyer, U.A. Am. J. Hum. Genet. (1991) [Pubmed]
  2. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene. Kimura, S., Umeno, M., Skoda, R.C., Meyer, U.A., Gonzalez, F.J. Am. J. Hum. Genet. (1989) [Pubmed]
  3. Determination of CYP2D6 gene copy number by pyrosequencing. Söderbäck, E., Zackrisson, A.L., Lindblom, B., Alderborn, A. Clin. Chem. (2005) [Pubmed]
 
WikiGenes - Universities