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Gene Review

DCLK2  -  doublecortin-like kinase 2

Homo sapiens

Synonyms: CL2, CLICK-II, CLICK2, CLIK2, CaMK-like CREB regulatory kinase 2, ...
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High impact information on DCLK2

  • Overexpression of DCK2 stabilizes the MT cytoskeleton against cold-induced depolymerization [1].
  • In sympathetic neurons, DCK2 is localized to the cell body and to the terminal segments of axons and dendrites [1].
  • DCK2 may represent a phosphorylation-dependent switch for the reversible control of MT dynamics in the vicinity of neuronal growth cones [1].


  1. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. Edelman, A.M., Kim, W.Y., Higgins, D., Goldstein, E.G., Oberdoerster, M., Sigurdson, W. J. Biol. Chem. (2005) [Pubmed]
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