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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mageb2  -  melanoma antigen, family B, 2

Mus musculus

Synonyms: Mage-b2, Mage-rs2, Smage2
 
 
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Disease relevance of Mageb2

  • One monoclonal antibody, smpG4A, specifically recognized a 43 kDa protein in lysates of Mage-b2 mRNA-positive sarcoma cells and of the testis [1].
 

High impact information on Mageb2

  • Since this region is syntenic to the human Xp21.1-p22.1 region, we conclude that Smage1 and Smage2 are homologous to the MAGE-Xp rather than to the MAGE-Xq genes [2].
  • The 5' noncoding region of Smage2 provides the potential for regulating the expression of the gene through several different promoters located in front of alternative first exons [2].
  • Immunohistochemistry showed that Mage-b2 is located in the nucleus of Mage-b2 mRNA-positive sarcoma cells [1].
 

Other interactions of Mageb2

  • Two of these mouse genes, Smage1 and Smage2, are more than 99% identical to each other and encode the same protein of 330 aa [2].

References

  1. Identification, expression, and nuclear location of murine Mage-b2 protein, a tumor-associated antigen. Lee, J.H., Sung, B.W., Youn, H.J., Park, J.H. Mol. Cells (2000) [Pubmed]
  2. Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes. De Backer, O., Verheyden, A.M., Martin, B., Godelaine, D., De Plaen, E., Brasseur, R., Avner, P., Boon, T. Genomics (1995) [Pubmed]
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