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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Orm2  -  orosomucoid 2

Mus musculus

Synonyms: AGP 2, Agp-2, Agp1, Alpha-1-acid glycoprotein 2, OMD 2, ...
 
 
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Disease relevance of Orm2

  • These studies suggest that the synthesis of specific C/EBP alpha and C/EBP beta isoforms is induced by hyperthermia, and that the regulation of the AGP-1 and AGP-2 genes during heat stress may involve one of these isoforms [1].
 

High impact information on Orm2

  • Two alpha 1-acid glycoproteins, termed AGP-1 and AGP-2, differing in size and charge, were found in all mice and appear to derive from distinct yet closely related mRNAs [2].
  • The major structural differences between AGP-2 and AGP-3 genes are located in introns 1 and 5 [3].
  • Adrenalectomy has no effect on the inductions by heavy metals of AGP-2 and the SAAs, indicating that the glucocorticoid receptor pathway may not function in this regulation [4].
 

Biological context of Orm2

  • In a genetic cross, electrophoretic polymorphisms for the two alpha 1-acid glycoproteins, AGP-1 and AGP-2, co-segregated in 58 backcross progeny, indicating that either a single gene or two tightly-linked genes on chromosome 4 encode the AGPs [5].

References

  1. Induction of a subgroup of acute phase protein genes in mouse liver by hyperthermia. Yiangou, M., Paraskeva, E., Hsieh, C.C., Markou, E., Victoratos, P., Scouras, Z., Papaconstantinou, J. Biochim. Biophys. Acta (1998) [Pubmed]
  2. The acute phase response of mouse liver. Genetic analysis of the major acute phase reactants. Baumann, H., Held, W.A., Berger, F.G. J. Biol. Chem. (1984) [Pubmed]
  3. Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3). Chang, C.J., Lai, M.Y., Chen, D.S., Lee, S.C. DNA Cell Biol. (1992) [Pubmed]
  4. The differential induction of alpha 1-acid glycoprotein and serum amyloid A genes by heavy metals. Yiangou, M., Papaconstantinou, J. Biochim. Biophys. Acta (1993) [Pubmed]
  5. Genetics and evolution of the acute phase proteins in mice. Baumann, H., Berger, F.G. Mol. Gen. Genet. (1985) [Pubmed]
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