Disease relevance of Socs7

• Six-month-old Socs7-deficient mice exhibited increased growth of pancreatic islets with mildly increased fasting insulin levels and hypoglycemia [1].

High impact information on Socs7

• Socs7-deficient mice exhibited lower glucose levels and prolonged hypoglycemia during an insulin tolerance test and increased glucose clearance in a glucose tolerance test [1].
• These data suggest that SOCS7 is a potent regulator of glucose homeostasis and insulin signaling [1].
• Socs7-/- mice were born in expected numbers, were fertile, and did not exhibit defects in hematopoiesis or circulating glucose or insulin concentrations [2].
• Development of hydrocephalus in mice lacking SOCS7 [2].
• We found that SOCS-6 and SOCS-7 are expressed ubiquitously in murine tissues [3].

Associations of Socs7 with chemical compounds

• We investigated the binding specificity of the SOCS-6 and SOCS-7 SH2 domains and found that they preferentially bound to phosphopeptides containing a valine in the phosphotyrosine (pY) +1 position and a hydrophobic residue in the pY +2 and pY +3 positions [3].

Analytical, diagnostic and therapeutic context of Socs7

• To investigate the physiological role of SOCS7, we have used gene targeting to generate mice that lack expression of the Socs7 gene [2].
• In situ hybridization studies revealed prominent expression of Socs7 in the brain, suggestive of an important functional role of SOCS7 in this organ [2].

References