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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GSTA5  -  glutathione S-transferase alpha 5

Homo sapiens

Synonyms: GST class-alpha member 5, Glutathione S-transferase A5, Glutathione S-transferase A5-5
 
 
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Disease relevance of GSTA5

 

High impact information on GSTA5

  • GSTA5 protein was not detected in hepatic cytosol of the two groups [2].
  • At the highest dose of D3T (0.3 mmol/kg), protein levels of GSTA5 and AFAR were induced by 7- and 27-fold, respectively [3].
  • We have used homology modelling, based on the crystal structure of the human glutathione S-transferase (GST) A1-1, to obtain the three-dimensional structures of rat GSTA3 and rat GSTA5 subunits bound to S-aflatoxinyl-glutathione [4].
  • Control and hypophysectomized rats of both sexes were used to study the role of growth hormone in the regulation of hepatic GSTA5; and the influence of testosterone on the expression of this same subunit was investigated in intact females and castrated males [5].

References

  1. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Yates, M.S., Kwak, M.K., Egner, P.A., Groopman, J.D., Bodreddigari, S., Sutter, T.R., Baumgartner, K.J., Roebuck, B.D., Liby, K.T., Yore, M.M., Honda, T., Gribble, G.W., Sporn, M.B., Kensler, T.W. Cancer Res. (2006) [Pubmed]
  2. Grapefruit juice intake does not enhance but rather protects against aflatoxin B1-induced liver DNA damage through a reduction in hepatic CYP3A activity. Miyata, M., Takano, H., Guo, L.Q., Nagata, K., Yamazoe, Y. Carcinogenesis (2004) [Pubmed]
  3. Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz. Roebuck, B.D., Curphey, T.J., Li, Y., Baumgartner, K.J., Bodreddigari, S., Yan, J., Gange, S.J., Kensler, T.W., Sutter, T.R. Carcinogenesis (2003) [Pubmed]
  4. Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases. McDonagh, P.D., Judah, D.J., Hayes, J.D., Lian, L.Y., Neal, G.E., Wolf, C.R., Roberts, G.C. Biochem. J. (1999) [Pubmed]
  5. Growth hormone- and testosterone-dependent regulation of glutathione transferase subunit A5 in rat liver. Staffas, L., Ellis, E.M., Hayes, J.D., Lundgren, B., Depierre, J.W., Mankowitz, L. Biochem. J. (1998) [Pubmed]
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