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Gene Review

Wfs1  -  Wolfram syndrome 1 homolog (human)

Mus musculus

Synonyms: AI481085, Wolframin, wolframin
 
 
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Disease relevance of Wfs1

 

High impact information on Wfs1

 

Biological context of Wfs1

 

Anatomical context of Wfs1

References

  1. Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis. Riggs, A.C., Bernal-Mizrachi, E., Ohsugi, M., Wasson, J., Fatrai, S., Welling, C., Murray, J., Schmidt, R.E., Herrera, P.L., Permutt, M.A. Diabetologia (2005) [Pubmed]
  2. Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic beta-cells via transcriptional activation. Ueda, K., Kawano, J., Takeda, K., Yujiri, T., Tanabe, K., Anno, T., Akiyama, M., Nozaki, J., Yoshinaga, T., Koizumi, A., Shinoda, K., Oka, Y., Tanizawa, Y. Eur. J. Endocrinol. (2005) [Pubmed]
  3. The WFS1 gene, responsible for low frequency sensorineural hearing loss and Wolfram syndrome, is expressed in a variety of inner ear cells. Cryns, K., Thys, S., Van Laer, L., Oka, Y., Pfister, M., Van Nassauw, L., Smith, R.J., Timmermans, J.P., Van Camp, G. Histochem. Cell Biol. (2003) [Pubmed]
 
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