High impact information on Wnt10a

• Wnt10a and full length Wnt10b encode relatively closely related (62% identity) Wnt proteins containing the 24 cysteines characteristic of most Wnt proteins [1].
• Wnt10a RNA was most abundant in adult brain with a high concentration in the pituitary gland, and expression of Wnt10b was highest in adult lung and uterus [1].
• Wnt10a and Wnt10b expression broadly peaked at approximately 13.5 and 15.5 days of gestation, respectively, and Northern blot analyses of RNAs from dissected embryos revealed that expression of both genes was strongest in the face, limbs and skin and that Wnt10a was also expressed in the liver, the major site of hematopoiesis in the embryo [1].
• These results suggest that Wnt10a is involved in AER formation in the chick limb bud through the Wnt/beta-catenin signaling pathway [2].
• The Wnt10a gene was expressed broadly in the surface ectoderm from as early as stage 10 [2].

Biological context of Wnt10a

• Chicken Wnt10a has 82% identity with mouse Wnt10a in the amino acid sequence [2].

Anatomical context of Wnt10a

• These expression patterns suggest that Wnt10a and Wnt10b may function in various tissues of the adult and embryo with notable expression in tissues responsible for the formation and maturation of blood cells, in the pituitary gland (Wnt10a), and in the face, limbs and skin of developing embryos [1].

References