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Gene Review:

ALDOA - aldolase A, fructose-bisphosphate

Homo sapiens

Synonyms: ALDA, Fructose-bisphosphate aldolase A, GSD12, HEL-S-87p, Lung cancer antigen NY-LU-1, ...

Kukita, A. et al., Yao, D.C. et al., Tilleman, K. et al., Semenza, G.L. et al., Asaka, M. et al.

Semenza, Jiang, Leung, Passantino, Concordet, Maire, Giallongo,

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Disease relevance of ALDOA

In this paper we characterize hypoxia response elements in the promoters of the ALDA, ENO1, and Ldha genes [1].

High impact information on ALDOA

Aldolase (E.C. 4.1.2.13), a homotetrameric protein encoded by the ALDOA gene, converts fructose-1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde-3-phosphate [2].
Molecular gene mapping of human aldolase A (ALDOA) gene to chromosome 16 [3].
Mapping of human aldolase A (ALDOA) gene was performed by molecular hybridization techniques using a panel of human-mouse cell hybrids and sorted fractions of human metaphase chromosomes besides in situ hybridization [3].
Fructose bisphosphate aldolase A and alpha-enolase showed higher expression levels in SpA than in OA (P < 0.01) [4].

Biological context of ALDOA

The results of RNA and DNA blot analyses indicated that the human ALDOA gene is located on chromosome 16 [3].

Analytical, diagnostic and therapeutic context of ALDOA

The in situ hybridization experiment also indicated that the ALDOA gene was localized to 16q22-q24 [3].
Sequence analysis of the ALDOA coding regions revealed 2 novel heterozygous ALDOA mutations in conserved regions of the protein [2].
Diagnosis of cancer by radioimmunoassay of muscle type aldolase [5].

References

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. Semenza, G.L., Jiang, B.H., Leung, S.W., Passantino, R., Concordet, J.P., Maire, P., Giallongo, A. J. Biol. Chem. (1996) [Pubmed]
Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). Yao, D.C., Tolan, D.R., Murray, M.F., Harris, D.J., Darras, B.T., Geva, A., Neufeld, E.J. Blood (2004) [Pubmed]
Molecular gene mapping of human aldolase A (ALDOA) gene to chromosome 16. Kukita, A., Yoshida, M.C., Fukushige, S., Sakakibara, M., Joh, K., Mukai, T., Hori, K. Hum. Genet. (1987) [Pubmed]
Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry. Tilleman, K., Van Beneden, K., Dhondt, A., Hoffman, I., De Keyser, F., Veys, E., Elewaut, D., Deforce, D. Proteomics (2005) [Pubmed]
Diagnosis of cancer by radioimmunoassay of muscle type aldolase. Asaka, M., Nagase, K., Shiraishi, T., Miyazaki, T. Gann = Gan. (1980) [Pubmed]

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ALDOA	Bos taurus
aldo-2	Caenorhabditis elegans
ALDOA	Canis lupus familiaris
aldoaa	Danio rerio
aldoab	Danio rerio
ALDOA	Macaca mulatta
Aldoa	Mus musculus
Os08g0120600	Oryza sativa Japonica Group
ALDOA	Pan troglodytes
Aldoa	Rattus norvegicus
aldoa	Xenopus (Silurana) tropicalis

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