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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Aph1a  -  anterior pharynx defective 1a homolog (C....

Mus musculus

Synonyms: 6530402N02Rik, APH-1a, Aph-1alpha, Gamma-secretase subunit APH-1A
 
 
 
 
 
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High impact information on Aph1a

  • Together, our findings establish that APH-1a is the major mammalian APH-1 homolog present in PS-dependent gamma-secretase complexes during embryogenesis and support the view that mammalian APH-1 isoforms define a set of distinct functional gamma-secretase complexes [1].
  • APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development [1].

References

  1. APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development. Ma, G., Li, T., Price, D.L., Wong, P.C. J. Neurosci. (2005) [Pubmed]
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