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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PHLPP2  -  PH domain and leucine rich repeat protein...

Homo sapiens

Synonyms: KIAA0931, PH domain leucine-rich repeat-containing protein phosphatase 2, PH domain leucine-rich repeat-containing protein phosphatase-like, PHLPP-like, PHLPPL
 
 
 
 
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Disease relevance of PHLPP2

  • Depletion of endogenous PHLPP2 variants in breast cancer cells revealed the Ser-1016 variant is less functional toward both Akt and PKC [1].

References

  1. Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C. Brognard, J., Niederst, M., Reyes, G., Warfel, N., Newton, A.C. J. Biol. Chem. (2009) [Pubmed]
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