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Gene Review

PSD3  -  pleckstrin and Sec7 domain containing 3

Homo sapiens

Synonyms: DKFZp761K1423, EFA6D, EFA6R, Epididymis tissue protein Li 20mP, Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6, ...
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Disease relevance of PSD3


High impact information on PSD3

  • RESULTS: Two genes showed a significantly (P< 0.05) lower expression in grade 3 tumors compared with tumors of lower grade (N33) or compared with normal controls and tumors with lower grade (EFA6R) [2].
  • RESULTS: Considerably reduced amplitudes, prolonged durations and slowed conduction velocities are obtained for the intracellular potentials of the PSD2 and PSD3 cases [3].
  • In addition, N33 and EFA6R showed a complete loss of expression in several ovarian cancer cell lines [2].


  1. Identification of novel genes associated with astrocytoma progression using suppression subtractive hybridization and real-time reverse transcription-polymerase chain reaction. van den Boom, J., Wolter, M., Blaschke, B., Knobbe, C.B., Reifenberger, G. Int. J. Cancer (2006) [Pubmed]
  2. Five genes from chromosomal band 8p22 are significantly down-regulated in ovarian carcinoma: N33 and EFA6R have a potential impact on overall survival. Pils, D., Horak, P., Gleiss, A., Sax, C., Fabjani, G., Moebus, V.J., Zielinski, C., Reinthaller, A., Zeillinger, R., Krainer, M. Cancer (2005) [Pubmed]
  3. Differences in potentials and excitability properties in simulated cases of demyelinating neuropathies. Part II. Paranodal demyelination. Stephanova, D.I., Daskalova, M. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2005) [Pubmed]
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