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Gene Review:

UL27 - type 1 membrane protein; contains a signal...

Human herpesvirus 1

Desai, P. et al., Desai, P. et al., Bras, F. et al.

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Disease relevance of UL27

In the present study UL27 (glycoprotein gB) of herpes simplex virus type 1 (KOS) is the target gene for mutation transfer and the upstream gene UL28, which specifies the ICP18.5 polypeptide, is the marker-rescue gene [1].

High impact information on UL27

Four of five transformants that supported the growth of the UL27 mutant also supported the growth of a UL27-UL28 double mutant [2].
Thus, the inversion should include genes UL27 to UL44 [3].

References

A genetic selection method for the transfer of HSV-1 glycoprotein B mutations from plasmid to the viral genome: preliminary characterization of transdominance and entry kinetics of mutant viruses. Desai, P., Homa, F.L., Person, S., Glorioso, J.C. Virology (1994) [Pubmed]
The size and symmetry of B capsids of herpes simplex virus type 1 are determined by the gene products of the UL26 open reading frame. Desai, P., Watkins, S.C., Person, S. J. Virol. (1994) [Pubmed]
The left border of the genomic inversion of pseudorabies virus contains genes homologous to the UL46 and UL47 genes of herpes simplex virus type 1, but no UL45 gene. Bras, F., Dezélée, S., Simonet, B., Nguyen, X., Vende, P., Flamand, A., Masse, M.J. Virus Res. (1999) [Pubmed]

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