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Gene Review

GNAI3  -  guanine nucleotide binding protein (G...

Homo sapiens

Synonyms: 87U6, ARCND1, G(i) alpha-3, Guanine nucleotide-binding protein G(k) subunit alpha
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High impact information on GNAI3

  • Surprisingly, the results revealed a small preferential zone of replication initiation, of at most 1.7 kb, located in a limited part of the GNAI3 - GNAT2 intergenic region [1].
  • GNAI3 is mapped to a region of conserved linkage between human chromosome 1 (locus 1p13) and mouse chromosome 3 (at 48.4 cM) [2].
  • Previous sequence analysis identified both members of the GSTM family and the GNAI3 gene within a cloned 120-kb region surrounding the AMPD2 locus [3].

Anatomical context of GNAI3

  • In this report we analyze the replication of an amplified genomic region encompassing the 3'-end of the GNAI3 gene, the entire GNAT2 gene and the intergenic region between them in exponentially growing Chinese hamster fibroblasts [1].


  1. oriGNAI3: a narrow zone of preferential replication initiation in mammalian cells identified by 2D gel and competitive PCR replicon mapping techniques. Toledo, F., Baron, B., Fernandez, M.A., Lachagès, A.M., Mayau, V., Buttin, G., Debatisse, M. Nucleic Acids Res. (1998) [Pubmed]
  2. The highly conserved Chinese hamster GNAI3 gene maps less than 60 kb from the AMPD2 gene and lacks the intronic U6 snRNA present in its human counterpart. Baron, B., Fernandez, M.A., Toledo, F., Le Roscouët, D., Mayau, V., Martin, N., Buttin, G., Debatisse, M. Genomics (1994) [Pubmed]
  3. GNAI3, GNAT2, AMPD2, GSTM are clustered in 120 kb of Chinese hamster chromosome 1q. Baron, B., Fernandez, M.A., Carignon, S., Toledo, F., Buttin, G., Debatisse, M. Mamm. Genome (1996) [Pubmed]
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