Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Tinf2 - Terf1 (TRF1)-interacting nuclear factor 2

Mus musculus

Synonyms: AW552114, D14Wsu146e, TERF1-interacting nuclear factor 2, TIN2, TRF1-interacting nuclear protein 2, ...

Chiang, Y.J. et al., Kim, S.H. et al.

Chiang, Kim, Tessarollo, Campisi, Hodes,

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High impact information on Tinf2

TIN2 is a negative regulator of telomere elongation that interacts with telomeric DNA repeat binding factor 1 (TRF1) and affects telomere length by a telomerase-dependent mechanism [1].
Our findings suggest that TIN2 has a role independent of telomere length regulation that is essential for embryonic development and cell viability [1].
Here we show that inactivation of the mouse TRF1-interacting protein 2 (TIN2) gene results in early embryonic lethality [1].
Our findings suggest that differences in TIN2 cannot explain the telomere length differences among Homo sapiens, M. musculus, and M. spretus [2].

Biological context of Tinf2

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway [1].

References

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Chiang, Y.J., Kim, S.H., Tessarollo, L., Campisi, J., Hodes, R.J. Mol. Cell. Biol. (2004) [Pubmed]
Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Kim, S.H., Parrinello, S., Kim, J., Campisi, J. Genomics (2003) [Pubmed]

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