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Gene Review: 

TCN2  -  transcobalamin II

Bos taurus

Synonyms: TC II, TC-2, TCII, Transcobalamin II, Transcobalamin-2
 
 
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High impact information on TCN2

  • We have labeled homogensous rabbit and human TCII with 125I-labeled N-succinimidyl-3-(4-hydroxyphenyl) propionate and have performed in vivo experiments in rabbits [1].
  • Myeloblasts contain a TC II-like protein almost exclusively but promyelocytes contain a TC I-like protein which increases as the cells mature whilst 'TC II' decreases [2].

References

  1. The role and fate of rabbit and human transcobalamin II in the plasma transport of vitamin B12 in the rabbit. Schneider, R.J., Burger, R.L., Mehlman, C.S., Allen, R.H. J. Clin. Invest. (1976) [Pubmed]
  2. The intercellular content of the three transcobalamins at various stages of normal and leukaemic myleoid cell development. Zittoun, J., Marquet, J., Zittoun, R. Br. J. Haematol. (1975) [Pubmed]
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