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PPP2R3B  -  protein phosphatase 2, regulatory subunit...

Homo sapiens

Synonyms: NYREN8, PP2A subunit B isoform PR48, PPP2R3L, PPP2R3LY, PR48, ...
 
 
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High impact information on PPP2R3B

  • These results suggest that dephosphorylation of Cdc6 by PP2A, mediated by a specific interaction with PR48, is a regulatory event controlling initiation of DNA replication in mammalian cells [1].
  • PR48 localizes to the nucleus of mammalian cells, and its forced overexpression perturbs cell cycle progression, causing a G(1) arrest [1].
  • Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region [2].
 

Biological context of PPP2R3B

  • PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells [1].
  • A novel regulatory subunit of PP2A, termed PR48, was identified by a yeast two-hybrid screen of a human placental cDNA library, using human Cdc6, an essential component of prereplicative complexes, as bait [1].

References

  1. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Yan, Z., Fedorov, S.A., Mumby, M.C., Williams, R.S. Mol. Cell. Biol. (2000) [Pubmed]
  2. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. Schiebel, K., Meder, J., Rump, A., Rosenthal, A., Winkelmann, M., Fischer, C., Bonk, T., Humeny, A., Rappold, G. Cytogenet. Cell Genet. (2000) [Pubmed]
 
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