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Gene Review:

IGKV1D-32 - immunoglobulin kappa variable 1D-32...

Homo sapiens

Synonyms: IGKV1D32, O9

Lim, P.L. et al., Caren, L.D. et al., Viret, J.F. et al.

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High impact information on IGKV1D-32

Vaccination with S. typhi Ty21a elicited antibody-secreting cell (ASC) responses specific for S. typhi O9, 12 lipopolysaccharide (LPS), as well as significant increases in levels of immunoglobulin G (IgG) and IgA antibodies to the same antigen in serum [1].
The new test (TUBEX) detects anti-Salmonella O9 (both immunoglobulin M [IgM] and IgG) antibodies in patients by inhibiting the binding between an anti-O9 IgM monoclonal antibody (MAb) conjugated to colored latex particles and S. typhi lipopolysaccharide (LPS) conjugated to magnetic latex particles [2].
In a double-blind study, mice were injected intraperitoneally with 0.2 ml 0.2% octoxynol-9 (O-9), 0.2 ml 0.2% nonoxynol-9 (N-9), or 0.2 ml saline (control) daily for 24 days [3].

Analytical, diagnostic and therapeutic context of IGKV1D-32

Mice receiving O-9 showed no significant differences from either control group in any of these tests [3].

References

Mucosal and systemic immune responses in humans after primary and booster immunizations with orally administered invasive and noninvasive live attenuated bacteria. Viret, J.F., Favre, D., Wegmüller, B., Herzog, C., Que, J.U., Cryz, S.J., Lang, A.B. Infect. Immun. (1999) [Pubmed]
One-step 2-minute test to detect typhoid-specific antibodies based on particle separation in tubes. Lim, P.L., Tam, F.C., Cheong, Y.M., Jegathesan, M. J. Clin. Microbiol. (1998) [Pubmed]
Immunotoxicology studies on octoxynol-9 and nonoxynol-9 in mice. Caren, L.D., Brunmeier, V. Toxicol. Lett. (1987) [Pubmed]

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