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Gene Review:

Rnf17 - ring finger protein 17

Mus musculus

Synonyms: MMIP-2, Mad member-interacting protein 2, Mmip-2, Mmip2, RING finger protein 17, ...

Pan, J. et al., Yin, X.Y. et al., Yin, X.Y. et al.

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High impact information on Rnf17

Rnf17-null round spermatids advanced to step 4 but failed to produce sperm [1].
Rnf17-deficient male mice were sterile and exhibited a complete arrest in round spermatids, demonstrating that Rnf17 encodes a novel key regulator of spermiogenesis [1].
Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones [2].
We generated cell lines in which Mmip-2/Rnf-17 was rendered glucocorticoid (GC)-inducible [2].

Other interactions of Rnf17

Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network [3].

References

RNF17, a component of the mammalian germ cell nuage, is essential for spermiogenesis. Pan, J., Goodheart, M., Chuma, S., Nakatsuji, N., Page, D.C., Wang, P.J. Development (2005) [Pubmed]
Mmip-2/Rnf-17 enhances c-Myc function and regulates some target genes in common with glucocorticoid hormones. Yin, X.Y., Grove, L.E., Prochownik, E.V. Oncogene (2001) [Pubmed]
Mmip-2, a novel RING finger protein that interacts with mad members of the Myc oncoprotein network. Yin, X.Y., Gupta, K., Han, W.P., Levitan, E.S., Prochownik, E.V. Oncogene (1999) [Pubmed]

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