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Gene Review

H3F3A  -  H3 histone, family 3A

Homo sapiens

Synonyms: H3.3A, H3F3
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High impact information on H3F3A

  • The human histone proteins that were characterized were H3.3A histone (NCBI accession number: 51859376), H2B histone (NCBI accession number: 1568557), H2A.5 histone (NCBI accession number: 70686), H1 (NCBI accession number: 22770677), and H2.1 histone (SwissProt accession number: P16403) [1].
  • In contrast to the H3.3B promoter, the promoter region of the H3.3A gene revealed neither a TATA nor any CCAAT boxes but an initiator element and several SP1 binding sequence motifs within an overall GC-rich sequence [2].
  • The functional relevance of the elements identified by sequence analysis was established using a reporter gene assay with deletion constructs of the H3.3A promoter [2].
  • In this assay a 256 bp fragment was sufficient for the full promoter activity and three promoter segments, each containing SP1 binding motifs, contribute to the H3.3A gene expression [2].
  • Localization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters [3].

Anatomical context of H3F3A


Other interactions of H3F3A

  • Therefore we cloned, sequenced and characterized the regulatory structures of the H3.3A gene and compared these with the corresponding regions in the H3.3B gene [2].


  1. Is the sigma2 receptor a histone binding protein? Colabufo, N.A., Berardi, F., Abate, C., Contino, M., Niso, M., Perrone, R. J. Med. Chem. (2006) [Pubmed]
  2. Differential expression of human replacement and cell cycle dependent H3 histone genes. Frank, D., Doenecke, D., Albig, W. Gene (2003) [Pubmed]
  3. Localization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters. Lin, X., Wells, D.E. Genomics (1997) [Pubmed]
  4. Regulation of the expression of histone H3.3 by differential polyadenylation. Feng, R., Tang, X., Becker, A., Berger, A., Ye, J., Akhmanova, A., Hennig, W. Genome (2005) [Pubmed]
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