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HCRTR1  -  hypocretin (orexin) receptor 1

Homo sapiens

Synonyms: Hypocretin receptor type 1, OX1R, Orexin receptor type 1, Ox-1-R, Ox1-R, ...
 
 
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Psychiatry related information on HCRTR1

 

High impact information on HCRTR1

  • Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes [2].
  • G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase [3].
  • Screening of the orexin signaling system detected a 408 isoleucine to valine mutation in HCRTR1 that showed significant genotypic association with polydipsic-hyponatremic schizophrenia (p = .012) [4].
  • Using a semiquantitative RT-PCR technique, the levels of messenger RNA (mRNA) for prepro-orexin, orexin A (OX1-R) and orexin B (OX2-R) receptors were 20-50% higher in rats receiving nicotine for 14 days at the level of 2-4 mg/kg day compared with rats receiving saline solvent alone [5].
  • Cultured neurons from the locus coeruleus (LC) and the nucleus tuberomammillaris (TM) were used, as well as HEK293A cells transfected with GIRK1 and 2, either human orexin receptor type 1 (OX1R) or type 2 (OX2R), mu opioid receptor and GFP cDNAs [6].
 

Biological context of HCRTR1

  • Signal transduction pathways of orexin receptors were examined using a nerve-like cell line transfected with orexin receptor type-1 (OX1R) and orexin receptor type-2 (OX2R) [7].
 

Anatomical context of HCRTR1

  • Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate [8].
 

Associations of HCRTR1 with chemical compounds

  • In animals treated with nicotine at 4 mg/kg x day, the expression levels of mRNA for prepro-orexin, OX1-R, and OX2-R were significantly higher compared with those in either the free-feeding control or pair-fed saline control rats [5].
 

Other interactions of HCRTR1

References

  1. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., Li, R., Hungs, M., Pedrazzoli, M., Padigaru, M., Kucherlapati, M., Fan, J., Maki, R., Lammers, G.J., Bouras, C., Kucherlapati, R., Nishino, S., Mignot, E. Nat. Med. (2000) [Pubmed]
  2. Reduced number of hypocretin neurons in human narcolepsy. Thannickal, T.C., Moore, R.Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., Siegel, J.M. Neuron (2000) [Pubmed]
  3. G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. Ammoun, S., Lindholm, D., Wootz, H., Akerman, K.E., Kukkonen, J.P. J. Biol. Chem. (2006) [Pubmed]
  4. Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. Meerabux, J., Iwayama, Y., Sakurai, T., Ohba, H., Toyota, T., Yamada, K., Nagata, R., Irukayama-Tomobe, Y., Shimizu, H., Yoshitsugu, K., Ohta, K., Yoshikawa, T. Biol. Psychiatry (2005) [Pubmed]
  5. Nicotine up-regulates expression of orexin and its receptors in rat brain. Kane, J.K., Parker, S.L., Matta, S.G., Fu, Y., Sharp, B.M., Li, M.D. Endocrinology (2000) [Pubmed]
  6. Effects of orexin (hypocretin) on GIRK channels. Hoang, Q.V., Bajic, D., Yanagisawa, M., Nakajima, S., Nakajima, Y. J. Neurophysiol. (2003) [Pubmed]
  7. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu, Y., Miwa, Y., Yamanaka, A., Yada, T., Shibahara, M., Abe, Y., Sakurai, T., Goto, K. J. Pharmacol. Sci. (2003) [Pubmed]
  8. Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate. Shiba, T., Ozu, M., Yoshida, Y., Mignot, E., Nishino, S. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  9. Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1. Magga, J., Bart, G., Oker-Blom, C., Kukkonen, J.P., Akerman, K.E., Näsman, J. Biochem. Pharmacol. (2006) [Pubmed]
 
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