Gene Review:
HCRTR1 - hypocretin (orexin) receptor 1
Homo sapiens
Synonyms:
Hypocretin receptor type 1, OX1R, Orexin receptor type 1, Ox-1-R, Ox1-R, ...
- A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., Nevsimalova, S., Aldrich, M., Reynolds, D., Albin, R., Li, R., Hungs, M., Pedrazzoli, M., Padigaru, M., Kucherlapati, M., Fan, J., Maki, R., Lammers, G.J., Bouras, C., Kucherlapati, R., Nishino, S., Mignot, E. Nat. Med. (2000)
- Reduced number of hypocretin neurons in human narcolepsy. Thannickal, T.C., Moore, R.Y., Nienhuis, R., Ramanathan, L., Gulyani, S., Aldrich, M., Cornford, M., Siegel, J.M. Neuron (2000)
- G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase. Ammoun, S., Lindholm, D., Wootz, H., Akerman, K.E., Kukkonen, J.P. J. Biol. Chem. (2006)
- Association of an orexin 1 receptor 408Val variant with polydipsia-hyponatremia in schizophrenic subjects. Meerabux, J., Iwayama, Y., Sakurai, T., Ohba, H., Toyota, T., Yamada, K., Nagata, R., Irukayama-Tomobe, Y., Shimizu, H., Yoshitsugu, K., Ohta, K., Yoshikawa, T. Biol. Psychiatry (2005)
- Nicotine up-regulates expression of orexin and its receptors in rat brain. Kane, J.K., Parker, S.L., Matta, S.G., Fu, Y., Sharp, B.M., Li, M.D. Endocrinology (2000)
- Effects of orexin (hypocretin) on GIRK channels. Hoang, Q.V., Bajic, D., Yanagisawa, M., Nakajima, S., Nakajima, Y. J. Neurophysiol. (2003)
- Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu, Y., Miwa, Y., Yamanaka, A., Yada, T., Shibahara, M., Abe, Y., Sakurai, T., Goto, K. J. Pharmacol. Sci. (2003)
- Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate. Shiba, T., Ozu, M., Yoshida, Y., Mignot, E., Nishino, S. Biochem. Biophys. Res. Commun. (2002)
- Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1. Magga, J., Bart, G., Oker-Blom, C., Kukkonen, J.P., Akerman, K.E., Näsman, J. Biochem. Pharmacol. (2006)