Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ABCB5 - ATP-binding cassette, sub-family B...

Homo sapiens

Synonyms: ABCB5alpha, ABCB5beta, ABCB5 P-gp, ATP-binding cassette sub-family B member 5, EST422562, ...

Frank, N.Y. et al., Frank, N.Y. et al.

Frank, Pendse, Lapchak, Margaryan, Shlain, Doeing, Sayegh, Frank,

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Disease relevance of ABCB5

Our results identify ABCB5 as a novel drug transporter and chemoresistance mediator in human malignant melanoma [1].

High impact information on ABCB5

We found that ABCB5 blockade significantly reversed resistance of G3361 melanoma cells to doxorubicin, an agent to which clinical melanomas have been found refractory, resulting in a 43% reduction in the LD50 from 4 to 2.3 micromol/L doxorubicin (P < 0.05) [1].
Our results identified ABCB5-mediated doxorubicin efflux transport as the underlying mechanism of resistance, because ABCB5 blockade significantly enhanced intracellular drug accumulation [1].
Moreover, our findings show that ABCB5 is a novel molecular marker for a distinct subset of chemoresistant, stem cell phenotype-expressing tumor cells among melanoma bulk populations and indicate that these chemoresistant cells can be specifically targeted via ABCB5 to enhance cytotoxic efficacy [1].
Consistent with this novel ABCB5 function and mechanism in doxorubicin resistance, gene expression levels of the transporter across a panel of human cancer cell lines used by the National Cancer Institute for drug screening correlated significantly with tumor resistance to doxorubicin (r = 0.44; P = 0.016) [1].
Here, we have cloned ABCB5, a rhodamine efflux transporter and novel member of the human P-glycoprotein family, which marks CD133-expressing progenitor cells among human epidermal melanocytes and determines as a regulator of membrane potential the propensity of this subpopulation to undergo cell fusion [2].

Chemical compound and disease context of ABCB5

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma [1].

Biological context of ABCB5

Thus, our findings define a molecular mechanism for cell fusion involving progenitor cells and show that fusion and resultant growth and differentiation are not merely spontaneous events, but phenomena regulated by ABCB5 P-glycoprotein [2].
Our findings show that polyploid ABCB5+ cells are generated by cell fusion and that this process is specifically enhanced by ABCB5 P-glycoprotein blockade [2].

Other interactions of ABCB5

Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter [2].

References

ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Frank, N.Y., Margaryan, A., Huang, Y., Schatton, T., Waaga-Gasser, A.M., Gasser, M., Sayegh, M.H., Sadee, W., Frank, M.H. Cancer Res. (2005)
Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. Frank, N.Y., Pendse, S.S., Lapchak, P.H., Margaryan, A., Shlain, D., Doeing, C., Sayegh, M.H., Frank, M.H. J. Biol. Chem. (2003)

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