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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SERINC2  -  serine incorporator 2

Homo sapiens

Synonyms: FKSG84, PRO0899, Serine incorporator 2, TDE2, TDE2L, ...
 
 
 
 
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Disease relevance of SERINC2

 

High impact information on SERINC2

  • In addition, we show that TDE2 is a potential transmembrane protein with 11 putative transmembrane helices [1].
  • Alternatively, only 2 of 18 tumors and 8 of 14 adjacent nonmalignant bronchiole epithelium regions demonstrated negative to low levels of TDE2 signals [1].
  • TDE2, a gene with sequence similarity to the mouse testicular tumor-differentially-expressed (Tde1/MUSTETU) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC) [1].
 

Analytical, diagnostic and therapeutic context of SERINC2

  • Using real-time quantitative PCR, we showed that TDE2 transcript levels were higher in NSCLC compared to nonmalignant samples [1].
  • By in situ hybridization, we showed that 10 of 18 lung tumors and only 1 of 14 adjacent nonmalignant regions had high levels of TDE2 transcripts [1].

References

  1. Identification of TDE2 gene and its expression in non-small cell lung cancer. Player, A., Gillespie, J., Fujii, T., Fukuoka, J., Dracheva, T., Meerzaman, D., Hong, K.M., Curran, J., Attoh, G., Travis, W., Jen, J. Int. J. Cancer (2003) [Pubmed]
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