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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SLC6A18  -  solute carrier family 6 (neutral amino...

Homo sapiens

Synonyms: FLJ31236, Sodium-and chloride-dependent transporter XTRP2, Sodium-dependent neutral amino acid transporter B(0)AT3, Solute carrier family 6 member 18, System B(0) neutral amino acid transporter AT3, ...
 
 
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High impact information on SLC6A18

  • This condensed domain was at least 100 kb in size and contained the intergenic region 5' to the hTERT gene and the downstream Xtrp2 locus [1].
  • In telomerase-negative cells, the inhibition of histone deacetylases by trichostatin A led to the opening of this chromatin domain, accompanied by transcription from the hTERT gene but not the Xtrp2 gene [1].
  • In contrast, the inhibition of protein synthesis by cycloheximide induced transcription from both the hTERT and Xtrp2 genes, indicating that histone deacetylases and labile factors coordinate to silence this chromosomal region [1].
  • These were named SLC6A17 and SLC6A18 by HUGO [2].

References

  1. The hTERT gene is embedded in a nuclease-resistant chromatin domain. Wang, S., Zhu, J. J. Biol. Chem. (2004) [Pubmed]
  2. The repertoire of solute carriers of family 6: identification of new human and rodent genes. Höglund, P.J., Adzic, D., Scicluna, S.J., Lindblom, J., Fredriksson, R. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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