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Gene Review

ITGB7  -  integrin, beta 7

Homo sapiens

Synonyms: Gut homing receptor beta subunit, Integrin beta-7
 
 
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Disease relevance of ITGB7

  • CONCLUSIONS: These findings indicate that neither the human ITGB7 nor the VDR gene seem to be associated with the pathogenesis of asthma or the expression of related allergic phenotypes such as eosinophilia and changes in total IgE level [1].
 

High impact information on ITGB7

  • In addition to these SNPs, five already described SNPs of the ITGB7 and one in the human VDR gene were analysed in a Caucasian sib pair study of 176 families with at least two affected children, using matrix assisted laser desorption/ionization time of flight mass spectrometry [1].
  • None of the eight analysed SNPs, of either the ITGB7 or the VDR genes, showed significant linkage/association with asthma or related phenotypes in the family study [1].
  • METHODS: All exons, including parts of the neighbouring introns, and the predicted promoter region of the ITGB7 gene were screened for common polymorphisms in 32 independent asthmatic and healthy probands, resulting in the detection of two single nucleotide polymorphisms (SNPs) unknown so far [1].
  • BACKGROUND: The human genes coding for integrin beta 7 (ITGB7) and vitamin D receptor (VDR) are two of the several candidate genes for asthma and related phenotypes found in a promising candidate region on chromosome 12q that has been identified in multiple genomewide screens and candidate gene approaches [1].
  • Isolation of the 5' region of the human ITGB7 integrin gene [2].
 

Analytical, diagnostic and therapeutic context of ITGB7

References

  1. Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma. Vollmert, C., Illig, T., Altmüller, J., Klugbauer, S., Loesgen, S., Dumitrescu, L., Wjst, M. Clin. Exp. Allergy (2004) [Pubmed]
  2. Isolation of the 5' region of the human ITGB7 integrin gene. Mead, P.E., Leung, E., Yang, Y., Jiang, W.M., Print, C.G., Harrison, J.E., Watson, J.D., Krissansen, G.W. Immunogenetics (1994) [Pubmed]
  3. A revised sequence of the human beta7 integrin gene (ITGB7) promoter region obtained by inverse PCR. van Heel, D.A., Allen, M., Jewell, D.P., Carey, A.H. Immunogenetics (2000) [Pubmed]
 
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