Disease relevance of MIA3

• These results taken together provide the first indications for a tumor suppressor role of TANGO gene in human malignant melanoma [1].
• Myeloma and bone disease: "the dangerous tango" [2].

High impact information on MIA3

• Tryptophan, indole, indole acetic acid, and tryptamine activated transcription in yeast coexpressing AHR and ARNT (EC50 values approximately 300 microM) [3].
• Functional assays with TANGO transfected or treated cell lines revealed that TANGO expression reduces motility, whereas reduction of TANGO enhances migration [1].
• In our study we revealed that TANGO was downregulated or lost in 9 melanoma cell lines when compared to normal melanocytes and in most of the 8 tumor samples analyzed [1].
• Dipyrone (metamizole) use in the United States: a lethal tango [4]?
• The tango and tangle of human papillomavirus and the human genome [5].

Associations of MIA3 with chemical compounds

• Yeast expressing AHR and ARNT displayed constitutive transcriptional activity that was not augmented by addition of AHR agonists in strains that required exogenous tryptophan for viability [3].

References