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Gene Review

prfA  -  peptide chain release factor 1

Staphylococcus aureus RF122

 
 
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Disease relevance of prfA

  • Sequencing of the vicinity of the staphylococcal pbp2 gene and transcriptional analysis by primer extension and promoter fusions were used to show that pbp2 is part of an operon that also includes a gene with high homology to prfA of Bacillus subtilis [1].
 

High impact information on prfA

  • The prs-prfA cluster-ldh region of the L. seeligeri isolates was approximately threefold shorter due to the loss of orfD, prfA, orfE, plcA, hly, orfK, mpl, actA, dplcB, plcB, orfH, orfX, and orfI [2].
 

Analytical, diagnostic and therapeutic context of prfA

  • All genes of the prfA cluster of L. seeligeri, located in the prs-ldh region, including the orfA2, orfD, prfA, orfE, plcA, hly, orfK, mpl, actA, dplcB, plcB, orfH, orfX, orfI, orfP, orfB, and orfA genes, were checked by PCR and direct sequencing for evidence of their presence in the atypical isolates [2].

References

  1. Transcriptional analysis of the Staphylococcus aureus penicillin binding protein 2 gene. Pinho, M.G., de Lencastre, H., Tomasz, A. J. Bacteriol. (1998) [Pubmed]
  2. Discovery of natural atypical nonhemolytic Listeria seeligeri isolates. Volokhov, D., George, J., Anderson, C., Duvall, R.E., Hitchins, A.D. Appl. Environ. Microbiol. (2006) [Pubmed]
 
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