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Gene Review

Ugt1a1  -  UDP glucuronosyltransferase 1 family,...

Mus musculus

Synonyms: Gnt1, UDP-glucuronosyltransferase 1-1, UDP-glucuronosyltransferase 1A1, UDPGT 1-1, UGT1*1, ...
 
 
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High impact information on Ugt1a1

  • In addition, CAR agonists upregulated bile acid-sulfating Sult2a1 and bilirubin-glucuronidating Ugt1a1 [1].
  • Nucleotide sequence comparison of rhesus UGT1A01 to other rhesus UGT1A isoforms detected a single-transition mutation at nucleotide 1520 (T-->C), resulting in a neutral F to S substitution at position 507 [2].

References

  1. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Wagner, M., Halilbasic, E., Marschall, H.U., Zollner, G., Fickert, P., Langner, C., Zatloukal, K., Denk, H., Trauner, M. Hepatology (2005) [Pubmed]
  2. Isolation and characterization of a UDP-glucuronosyltransferase (UGT1A01) cloned from female rhesus monkey. Dean, B., Chang, S., Stevens, J., Thomas, P.E., King, C. Arch. Biochem. Biophys. (2002) [Pubmed]
 
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