Disease Relevance of MIRN184

• Rett syndrome. [1]
• Elevation of miR-184 was observed in squamous cell carcinoma of the tongue and inhibition of miR-184 reduced proliferation of tongue SCC cell lines slightly.[2]
• all-trans-retinoic acid induces miR-184 expression in a neuroblastoma cell line and ectopic miR-184 causes apoptosis. [3]. This is mediated at least in part by miR-184-dependent reduction of AKT2 expression [4]
• miR-184 has also been implicated in ischemia-induced retinal neovascularization. [5]

High impact information on miR-184

• miR-184 is the first miRNA shown to inhibit the function of another. Specifically, miR-184 interferes with the binding of miR-205 to the 3' UTR of SHIP2 (INNPL1), inhibiting miR-205-dependent suppression of SHIP2.[6]
• miR-184 blocks expression of NFAT1 protein without destabilizing the mRNA transcript. [7]

Expression

• miR-184 is abundant in the corneal epithelium. [8]
• High miR-184 expression was observed in mouse testis, with lower expression in brain tissue. [1]
• Depolarization of cortical neurons resulted in pri-miR-184 expression in an allele-specific manner. [1]
• The expression of miR-184 detected in umbilical cord blood-derived CD4(+) T cells was 58.4-fold higher than that observed in adult blood CD4(+) T cells. [7]

Other interactions of miR-184

• In Drosophila S2 cells, miR-184 appeared to repress some target mRNAs by binding to specific sites in their coding regions [9].

References