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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MAGEA2  -  melanoma antigen family A, 2

Homo sapiens

Synonyms: CT1.2, MAGE2, MAGEA2A, melanoma antigen family A2
 
 
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Disease relevance of MAGEA2

  • A recent report indicated that fresh uveal melanoma tissue and metastatic tumor biopsies failed to express melanoma antigen gene (MAGE)-1, MAGE-2, or MAGE-3 [1].
 

High impact information on MAGEA2

  • Moreover, the 72-kDa protein does not appear to be a product of the other members of the MAGE gene family known to be expressed in tumors (such as MAGE-2, -3, -4 and -12) [2].
  • Similar differences in the frequency of gene expression between primary and metastatic tumor samples were observed for MAGE-2, MAGE-3, and MAGE-4 [3].

References

  1. Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease. Chen, P.W., Murray, T.G., Uno, T., Salgaller, M.L., Reddy, R., Ksander, B.R. Clin. Exp. Metastasis (1997) [Pubmed]
  2. Monoclonal antibodies against recombinant-MAGE-1 protein identify a cross-reacting 72-kDa antigen which is co-expressed with MAGE-1 protein in melanoma cells. Carrel, S., Schreyer, M., Spagnoli, G., Cerottini, J.C., Rimoldi, D. Int. J. Cancer (1996) [Pubmed]
  3. Expression of MAGE genes in primary and metastatic cutaneous melanoma. Brasseur, F., Rimoldi, D., Liénard, D., Lethé, B., Carrel, S., Arienti, F., Suter, L., Vanwijck, R., Bourlond, A., Humblet, Y. Int. J. Cancer (1995) [Pubmed]
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