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Gene Review:

MAN2A2 - mannosidase, alpha, class 2A, member 2

Homo sapiens

Synonyms: Alpha-mannosidase 2x, Alpha-mannosidase IIx, HsT19662, MANA2X, Man IIx, ...

Oh-Eda, M. et al., Misago, M. et al.

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High impact information on MAN2A2

When coexpressed with alpha-mannosidase II, alpha-mannosidase IIx colocalizes with alpha-mannosidase II in COS cells [1].
A protein A fusion of the catalytic domain of alpha-mannosidase IIx hydrolyzes a synthetic substrate, 4-umbelliferyl-alpha-D-mannoside, and this activity is inhibited by swainsonine [1].
Here, we show by immunocytochemistry that alpha-mannosidase IIx resides in the Golgi in HeLa cells [1].

Other interactions of MAN2A2

Previously, we isolated a cDNA encoding a protein homologous to alpha-mannosidase II and designated it alpha-mannosidase IIx [1].

Analytical, diagnostic and therapeutic context of MAN2A2

Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme [2].

References

Overexpression of the Golgi-localized enzyme alpha-mannosidase IIx in Chinese hamster ovary cells results in the conversion of hexamannosyl-N-acetylchitobiose to tetramannosyl-N-acetylchitobiose in the N-glycan-processing pathway. Oh-Eda, M., Nakagawa, H., Akama, T.O., Lowitz, K., Misago, M., Moremen, K.W., Fukuda, M.N. Eur. J. Biochem. (2001) [Pubmed]
Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme. Misago, M., Liao, Y.F., Kudo, S., Eto, S., Mattei, M.G., Moremen, K.W., Fukuda, M.N. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]

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