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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

RAD18  -  RAD18 homolog (S. cerevisiae)

Gallus gallus

 
 
 
 
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Disease relevance of RAD18

  • Concomitant deletion of Rad18 and PARP1 synergistically increased CPT sensitivity, and additional inactivation of NHEJ normalized this hypersensitivity, indicating their parallel actions [1].

References

  1. RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair. Saberi, A., Hochegger, H., Szuts, D., Lan, L., Yasui, A., Sale, J.E., Taniguchi, Y., Murakawa, Y., Zeng, W., Yokomori, K., Helleday, T., Teraoka, H., Arakawa, H., Buerstedde, J.M., Takeda, S. Mol. Cell. Biol. (2007) [Pubmed]
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