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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BCL2L15  -  BCL2-like 15

Homo sapiens

Synonyms: Bcl-2-like protein 15, Bcl2-L-15, Bfk, C1orf178, FLJ22588
 
 
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High impact information on C1orf178

  • Enforced expression of Bfk weakly promoted apoptosis and antagonized Bcl-2's prosurvival function [1].
  • Low amounts of Bfk were found in stomach, ovary, bone marrow and spleen, but its level in the mammary gland rose markedly during pregnancy, suggesting that Bfk may play a role in mammary development [1].
  • Like Bcl-G(L), Bfk did not bind to any Bcl-2 family members, even though its BH3 motif can mediate association with prosurvival proteins [1].
  • The human homologue of the pro-apoptotic Bcl-2 protein, Bfk, is predominantly expressed in tissues of the gastrointestinal tract [2].

References

  1. Bfk: a novel weakly proapoptotic member of the Bcl-2 protein family with a BH3 and a BH2 region. Coultas, L., Pellegrini, M., Visvader, J.E., Lindeman, G.J., Chen, L., Adams, J.M., Huang, D.C., Strasser, A. Cell Death Differ. (2003) [Pubmed]
  2. Expression of pro-apoptotic Bfk isoforms reduces during malignant transformation in the human gastrointestinal tract. Dempsey, C.E., Dive, C., Fletcher, D.J., Barnes, F.A., Lobo, A., Bingle, C.D., Whyte, M.K., Renshaw, S.A. FEBS Lett. (2005) [Pubmed]
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