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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TAS2R13  -  taste receptor, type 2, member 13

Homo sapiens

Synonyms: T2R13, TRB3, Taste receptor family B member 3, Taste receptor type 2 member 13
 
 
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Disease relevance of TAS2R13

 

High impact information on TAS2R13

  • PGC-1alpha or PGC-1beta overexpression upregulated GLUT4 mRNA and downregulated myocyte enhancer factor 2C transcription factor mRNA; only PGC-1alpha overexpression caused an increase in the mRNA expression of TRB3, a negative regulator of insulin signaling [2].
  • TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism [1].
  • Indeed, adipocytes deficient in TRB3 accumulated larger amounts of ACC protein than did wild-type cells [1].
  • Here, we describe a parallel pathway, in which the pseudokinase Tribbles 3 (TRB3), whose abundance is increased during fasting, stimulates lipolysis by triggering the degradation of ACC in adipose tissue [1].

References

  1. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Qi, L., Heredia, J.E., Altarejos, J.Y., Screaton, R., Goebel, N., Niessen, S., Macleod, I.X., Liew, C.W., Kulkarni, R.N., Bain, J., Newgard, C., Nelson, M., Evans, R.M., Yates, J., Montminy, M. Science (2006) [Pubmed]
  2. PGC-1{alpha} and PGC-1beta have both similar and distinct effects on myofiber switching toward an oxidative phenotype. Mortensen, O.H., Frandsen, L., Schjerling, P., Nishimura, E., Grunnet, N. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
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