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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

VRK3  -  vaccinia related kinase 3

Homo sapiens

Synonyms: Inactive serine/threonine-protein kinase VRK3, Serine/threonine-protein pseudokinase VRK3, Vaccinia-related kinase 3
 
 
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Disease relevance of VRK3

  • Here, we show that VRK3 suppresses ERK activity through direct binding to one of the MKPs, vaccinia H1-related (VHR), which specifically dephosphorylates and inactivates ERK in the nucleus [1].
 

High impact information on VRK3

  • This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3 [2].
  • The VRK3 proteins have key amino acid substitutions that disrupt invariant motifs required for catalytic activity, rendering them enzymatically inert [2].
  • VRK2 is expressed at lower levels than VRK1 and VRK3 in the mouse embryo [3].

References

  1. Negative regulation of ERK activity by VRK3-mediated activation of VHR phosphatase. Kang, T.H., Kim, K.T. Nat. Cell Biol. (2006) [Pubmed]
  2. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. Nichols, R.J., Traktman, P. J. Biol. Chem. (2004) [Pubmed]
  3. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. Vega, F.M., Gonzalo, P., Gaspar, M.L., Lazo, P.A. FEBS Lett. (2003) [Pubmed]
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