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Gene Review:

BFAR - bifunctional apoptosis regulator

Homo sapiens

Synonyms: BAR, Bifunctional apoptosis regulator, RING finger protein 47, RNF47

Roth, W. et al., Stegh, A.H. et al., Bianchini, M. et al.

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High impact information on BFAR

The bifunctional apoptosis regulator (BAR) is a multidomain protein that was originally identified as an inhibitor of Bax-induced apoptosis [1].
Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein [2].
For example, a significant number of these genes serve as apoptotic inhibitors (e.g. BFAR, BIRC1, BIRC6) [3].

References

Bifunctional apoptosis inhibitor (BAR) protects neurons from diverse cell death pathways. Roth, W., Kermer, P., Krajewska, M., Welsh, K., Davis, S., Krajewski, S., Reed, J.C. Cell Death Differ. (2003) [Pubmed]
Inactivation of caspase-8 on mitochondria of Bcl-xL-expressing MCF7-Fas cells: role for the bifunctional apoptosis regulator protein. Stegh, A.H., Barnhart, B.C., Volkland, J., Algeciras-Schimnich, A., Ke, N., Reed, J.C., Peter, M.E. J. Biol. Chem. (2002) [Pubmed]
Comparative study of gene expression by cDNA microarray in human colorectal cancer tissues and normal mucosa. Bianchini, M., Levy, E., Zucchini, C., Pinski, V., Macagno, C., De Sanctis, P., Valvassori, L., Carinci, P., Mordoh, J. Int. J. Oncol. (2006) [Pubmed]

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BFAR	Gallus gallus
BFAR	Macaca mulatta
Bfar	Mus musculus
BFAR	Pan troglodytes
Bfar	Rattus norvegicus
bfar	Xenopus (Silurana) tropicalis

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