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CDK14  -  cyclin-dependent kinase 14

Homo sapiens

Synonyms: Cell division protein kinase 14, Cyclin-dependent kinase 14, KIAA0834, PFTAIRE1, PFTK1, ...
 
 
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High impact information on PFTK1

  • In addition, treatment of 8-Br-cGMP significantly increased PFTK1 mRNA levels, and a specific inhibitor of cGMP production, ODQ, completely blocked TRH-induced expression of PFTK1 mRNA [1].
  • These findings demonstrated, for the first time, a novel pathway between a neuropeptide and a cell cycle related peptide in the brain, and PFTK1 may be a key regulator for TRH action in t he cerebellum through t he NO-cGMP pathway [1].
  • PFTK1 mRNA levels in the euthyroid TRH-1- cerebellum supplemented with thyroid hormone were significantly decreased compared with those in the wild-type [1].
  • Four clones among them were identical and cdc2-related kinase (PFTAIRE protein kinase 1 (PFTK1)) cDNA, which was previously reported to be expressed only in the brain and testis [1].
  • We have demonstrated by in situ hybridization and indirect immunofluorescence that several populations of terminally differentiated neurons and some neuroglia expressed PFTAIRE mRNA and protein [2].
 

Biological context of PFTK1

  • We deleted the POZ/BTB and Krüpel zinc finger domains, respectively, and observed the interaction between hPFTAIRE1 and truncated PLZFs by liquid beta-galactosidase activity assay [3].
 

Other interactions of PFTK1

 

Analytical, diagnostic and therapeutic context of PFTK1

  • By Northern blotting analysis, an approximately 6 kb transcript is detected with varied levels of expression of the hPFTAIRE1 in 16 human tissues [5].

References

  1. A novel TRH-PFTAIRE protein kinase 1 pathway in the cerebellum: subtractive hybridization analysis of TRH-deficient mice. Hashida, T., Yamada, M., Hashimoto, K., Shibusawa, N., Monden, T., Satoh, T., Mori, M. Endocrinology (2002) [Pubmed]
  2. A novel cdc2-related protein kinase expressed in the nervous system. Lazzaro, M.A., Albert, P.R., Julien, J.P. J. Neurochem. (1997) [Pubmed]
  3. Analysis of the interaction between hPFTAIRE1 and PLZF in a yeast two-hybrid system. Gao, Y.K., Jiang, M., Yang, T., Chen, J.Y. Acta Biochim. Biophys. Sin. (Shanghai) (2006) [Pubmed]
  4. KIAA0202, a human septin family member, interacting with hPFTAIRE1. Yang, T., Gao, Y.K., Chen, J.Y. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (2002) [Pubmed]
  5. Identification and cellular localization of human PFTAIRE1. Yang, T., Chen, J.Y. Gene (2001) [Pubmed]
 
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