Disease relevance of Slc46a1

• Intestinal Hcp1 mRNA content was not significantly changed by iron overload (600 mg/kg); however, it was increased to 170 % of controls 72 h after withdrawal of 0.7 ml of blood; the same treatment increased intestinal Cybrd1 mRNA to 900 % of controls [1].

High impact information on Slc46a1

• These results suggest that HCP-1 is a centromere-associated protein that is involved in the fidelity of chromosome segregation [2].
• When expression of HCP-1 is reduced by RNA interference (RNAi), staining with mAb 6C4 is eliminated, indicating that hcp-1 encodes the major mAb 6C4 antigen [2].
• We also identified a second protein from the C. elegans genome sequence database, HCP-2, that is 54% similar to HCP-1 [2].
• HCP-1, a protein involved in chromosome segregation, is localized to the centromere of mitotic chromosomes in Caenorhabditis elegans [2].
• Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium [3].

Biological context of Slc46a1

• Using quantitative real-time PCR, we examined the expression of Hcp1 and other intestinal iron-transporting proteins in male C57BL/6 mice with experimentally altered iron homeostasis [1].

References