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DDX56  -  DEAD (Asp-Glu-Ala-Asp) box helicase 56

Homo sapiens

Synonyms: ATP-dependent 61 kDa nucleolar RNA helicase, DDX21, DDX26, DEAD box protein 21, DEAD box protein 56, ...
 
 
 
 
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High impact information on DDX56

  • The specific intracellular localization and its striking sequence homology to other known RNA helicases lead to the hypothesis that protein NOH61 might be involved in ribosome synthesis, most likely during the assembly process of the large (60S) ribosomal subunit [1].
  • Treatment of cultured cells with 1) the transcription inhibitor actinomycin D and 2) RNase A results in a complete dissociation of NOH61 from nucleolar structures [1].
 

Anatomical context of DDX56

  • Interestingly, protein NOH61 has also been identified as a specific constituent of free nucleoplasmic 65S preribosomal particles but is absent from cytoplasmic ribosomes [1].

References

  1. A novel helicase-type protein in the nucleolus: protein NOH61. Zirwes, R.F., Eilbracht, J., Kneissel, S., Schmidt-Zachmann, M.S. Mol. Biol. Cell (2000) [Pubmed]
 
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