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Gene Review

NPLOC4  -  nuclear protein localization 4 homolog (S....

Homo sapiens

Synonyms: FLJ20657, KIAA1499, NPL4, Nuclear protein localization protein 4 homolog, Protein NPL4
 
 
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High impact information on NPLOC4

  • Yeast Ufd1p is required for ubiquitin-dependent protein degradation whereas yeast Npl4p has been implicated in nuclear transport [1].
  • However, contrary to the effects of proteasome inhibition, RNAi of Ufd1 or Npl4 does not induce an accumulation of alpha-TCR and delta-CD3, two ERAD substrates overexpressed in HeLa cells [2].
  • RNAi of Ufd1 or Npl4 is associated with a 2-fold increase in the levels of polyubiquitinated proteins, which form dispersed aggregates often associated with calnexin-positive structures [2].
  • Glutathione S-transferase pull-down experiments showed that all three VCP mutations do not affect the binding to Ufd1, Npl4 and ataxin-3 [3].

References

  1. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. Meyer, H.H., Shorter, J.G., Seemann, J., Pappin, D., Warren, G. EMBO J. (2000) [Pubmed]
  2. Destabilization of the VCP-Ufd1-Npl4 complex is associated with decreased levels of ERAD substrates. Nowis, D., McConnell, E., Wójcik, C. Exp. Cell Res. (2006) [Pubmed]
  3. Pathological consequences of VCP mutations on human striated muscle. Hübbers, C.U., Clemen, C.S., Kesper, K., Böddrich, A., Hofmann, A., Kämäräinen, O., Tolksdorf, K., Stumpf, M., Reichelt, J., Roth, U., Krause, S., Watts, G., Kimonis, V., Wattjes, M.P., Reimann, J., Thal, D.R., Biermann, K., Evert, B.O., Lochmüller, H., Wanker, E.E., Schoser, B.G., Noegel, A.A., Schröder, R. Brain (2007) [Pubmed]
 
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