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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DDX28  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 28

Homo sapiens

Synonyms: FLJ11282, MDDX28, Mitochondrial DEAD box protein 28
 
 
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High impact information on DDX28

  • The human protein MDDX28 is a putative RNA helicase and a nucleocytoplasmic shuttling protein also localized to the mitochondria [1].
  • We have studied its intracellular targeting signals and show that the first 20 amino acids of MDDX28 are necessary and sufficient for both mitochondrial import and nuclear export of the protein [1].
  • The nuclear localization of MDDX28 depended on active RNA polymerase II transcription, suggesting that the protein could be transported to and from the nucleus [2].
  • A cDNA encoding a novel member of the helicase family, MDDX28, has been cloned from a human testis library [2].
  • Regulated compartmentalization of the putative DEAD-box helicase MDDX28 within the mitochondria in COS-1 cells [3].
 

Biological context of DDX28

 

Anatomical context of DDX28

References

  1. Transport signals and transcription-dependent nuclear localization of the putative DEAD-box helicase MDDX28. Valgardsdottir, R., Prydz, H. J. Biol. Chem. (2003) [Pubmed]
  2. Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization. Valgardsdottir, R., Brede, G., Eide, L.G., Frengen, E., Prydz, H. J. Biol. Chem. (2001) [Pubmed]
  3. Regulated compartmentalization of the putative DEAD-box helicase MDDX28 within the mitochondria in COS-1 cells. Valgardsdottir, R., Ottersen, O.P., Prydz, H. Exp. Cell Res. (2004) [Pubmed]
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