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Gene Review

DDX28  -  DEAD (Asp-Glu-Ala-Asp) box polypeptide 28

Homo sapiens

Synonyms: FLJ11282, MDDX28, Mitochondrial DEAD box protein 28
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High impact information on DDX28

  • The human protein MDDX28 is a putative RNA helicase and a nucleocytoplasmic shuttling protein also localized to the mitochondria [1].
  • We have studied its intracellular targeting signals and show that the first 20 amino acids of MDDX28 are necessary and sufficient for both mitochondrial import and nuclear export of the protein [1].
  • The nuclear localization of MDDX28 depended on active RNA polymerase II transcription, suggesting that the protein could be transported to and from the nucleus [2].
  • A cDNA encoding a novel member of the helicase family, MDDX28, has been cloned from a human testis library [2].
  • Regulated compartmentalization of the putative DEAD-box helicase MDDX28 within the mitochondria in COS-1 cells [3].

Biological context of DDX28


Anatomical context of DDX28


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