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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

P3h1  -  prolyl 3-hydroxylase 1

Mus musculus

Synonyms: 2410024C15Rik, Gros1, Growth suppressor 1, Lepre1, Leprecan-1, ...
 
 
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Disease relevance of Lepre1

 

High impact information on Lepre1

  • Gros1, a potential growth suppressor on chromosome 1: its identity to basement membrane-associated proteoglycan, leprecan [2].
  • Within this segment, we identified two sets of residues [ERGA --> DKGT (522-525) and T578C] that, when replaced by their NBD2 counterparts, cause dramatic alterations of the substrate specificity of the protein [Beaudet, L., and Gros, P. (1995) J. Biol. Chem. 270, 17159-17170] [3].
  • Previously [Luz et al. (1994) Biochemistry 33, 7239-7249], we determined that Cl(-)- and -HCO3-dependent pHi homeostasis was perturbed in multidrug resistant (MDR) cells created by transfecting LR73 Chinese hamster ovary fibroblasts with wild-type mu (murine) MDR 1 (Gros et al., 1991) [4].
  • A cell line that overexpresses crippled MDR protein (S941F) that is not resistant to colchicine or doxorubicin, but which is resistant to vinblastine [Gros, P., Dhir, R., Croop, J., & Talbot, F. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 7289-7293], exhibits elevated pHi and slightly elevated delta psi, relative to LR73 [5].

References

  1. Characterization of the induction of persistent I-A expression by macrophages from Bcgr mice. Faris, M., Zwilling, B.S. J. Leukoc. Biol. (1991) [Pubmed]
  2. Gros1, a potential growth suppressor on chromosome 1: its identity to basement membrane-associated proteoglycan, leprecan. Kaul, S.C., Sugihara, T., Yoshida, A., Nomura, H., Wadhwa, R. Oncogene (2000) [Pubmed]
  3. Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity. Beaudet, L., Urbatsch, I.L., Gros, P. Biochemistry (1998) [Pubmed]
  4. Novel Cl(-)-dependent intracellular pH regulation in murine MDR 1 transfectants and potential implications. Roepe, P.D., Weisburg, J.H., Luz, J.G., Hoffman, M.M., Wei, L.Y. Biochemistry (1994) [Pubmed]
  5. Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells. Luz, J.G., Wei, L.Y., Basu, S., Roepe, P.D. Biochemistry (1994) [Pubmed]
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