The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt
  • Ensembl

Table of contents

About

Terms

 

Gene Review: 

Prl2a1  -  prolactin family 2, subfamily a, member 1

Mus musculus

Synonyms: PLP-M, PRL-like protein M, Placental prolactin-like protein M, Prlpm, Prolactin-2A1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Prl2a1

  • Invading mouse trophoblast cells also possess endocrine activities, including the expression of PLP-M and PLP-N [1].
  • PLP-L mRNA expression is observed from Days 11-20, with highest levels at Day 13; highest levels of PLP-M are observed from Day 11 until parturition, with peak levels also on Day 13; and highest levels of PRP are also observed from Day 11 until term, with maximal expression on Day 17 [2].
  • The encoded proteins of the two novel clones, designated prolactin-like proteins L (PLP-L) and M (PLP-M), are predicted to be synthesized as precursors of 229 and 227 amino acids, modified by N-linked glycosylation, and secreted as mature glycoproteins of 199 and 200 residues, respectively [2].
  • Information is also presented on the existence of multiple PLP-M transcripts, which are generated by alternative splicing [3].
  • The rat PLP-K cDNA encodes for a predicted 228 amino acid protein containing a 31 amino acid signal peptide and one putative N-linked glycosylation site; the mouse PLP-M cDNA encodes for a predicted 228 amino acid protein containing a 28 amino acid signal peptide and one putative N-linked glycosylation site [4].

References

  1. Gestation stage-dependent intrauterine trophoblast cell invasion in the rat and mouse: novel endocrine phenotype and regulation. Ain, R., Canham, L.N., Soares, M.J. Dev. Biol. (2003) [Pubmed]
  2. Identification of three prolactin-related hormones as markers of invasive trophoblasts in the rat. Toft, D.J., Linzer, D.I. Biol. Reprod. (2000) [Pubmed]
  3. The rat prolactin gene family locus: species-specific gene family expansion. Alam, S.M., Ain, R., Konno, T., Ho-Chen, J.K., Soares, M.J. Mamm. Genome (2006) [Pubmed]
  4. Three novel paralogs of the rodent prolactin gene family. Dai, G., Wang, D., Liu, B., Kasik, J.W., Müller, H., White, R.A., Hummel, G.S., Soares, M.J. J. Endocrinol. (2000) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities