The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Nespas  -  neuroendocrine secretory protein antisense

Mus musculus

Synonyms: Gnas-as, Nespos
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Nespas

  • Uniquely, the Nespas DMR acts on the downstream ICR at exon 1A to regulate tissue-specific imprinting of the Gnas gene [1].
  • We show that a paternally derived targeted deletion of the germline differentially methylated region (DMR) associated with the antisense Nespas transcript unexpectedly affects both the expression of all transcripts in the cluster and methylation of two DMRs [1].
  • These variants do not correspond to exons of the human antisense transcript although they start in the same region; the Nespas transcript, like its human counterpart, is spliced in various alternative patterns [2].

Biological context of Nespas

  • We propose that Nespas is an additional control element in the imprinting region of mouse distal Chr 2; it adds further complexity to the Gnas-imprinted gene cluster [3].

Anatomical context of Nespas


  1. Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster. Williamson, C.M., Turner, M.D., Ball, S.T., Nottingham, W.T., Glenister, P., Fray, M., Tymowska-Lalanne, Z., Plagge, A., Powles-Glover, N., Kelsey, G., Maconochie, M., Peters, J. Nat. Genet. (2006) [Pubmed]
  2. Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster. Williamson, C.M., Skinner, J.A., Kelsey, G., Peters, J. Mamm. Genome (2002) [Pubmed]
  3. An imprinted transcript, antisense to Nesp, adds complexity to the cluster of imprinted genes at the mouse Gnas locus. Wroe, S.F., Kelsey, G., Skinner, J.A., Bodle, D., Ball, S.T., Beechey, C.V., Peters, J., Williamson, C.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus. Coombes, C., Arnaud, P., Gordon, E., Dean, W., Coar, E.A., Williamson, C.M., Feil, R., Peters, J., Kelsey, G. Mol. Cell. Biol. (2003) [Pubmed]
  5. The spatial and temporal expression pattern of Nesp and its antisense Nespas, in mid-gestation mouse embryos. Ball, S.T., Williamson, C.M., Hayes, C., Hacker, T., Peters, J. Mech. Dev. (2001) [Pubmed]
WikiGenes - Universities