Disease relevance of SCYL1

• Scyl1 (NTKL) is located on 11q13 and is mapped around chromosomal breakpoints found in several carcinomas, suggesting that NTKL dysfunction may be involved in carcinogenesis [1].
• Scyl1 is the disease causing mutation in mdf mice that suffer from Spinocerebellar neurodegeneration and are a murine model of human Spinocerebellar ataxia and Spinomuscular atrophy.

High impact information on SCYL1

• Alternative splicing generates two variant forms of NTKL mRNA that encode protein isoforms with internal deletions [1].
• A fraction of endogenous NTKL protein is also localized to the centrosomes during mitosis [1].
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Biological context of SCYL1

• Data links Scyl1 to membrane trafficking in the secretory pathway.

Associations of SCYL1 with chemical compounds

Physical interactions of SCYL1

• A novel mouse protein was identified as an NTKL-binding protein (NTKL-BP1) by yeast two-hybrid screening, and the full-length cDNA was amplified based on the result of a sequence data analysis cloning strategy [2].
• Scyl1 interacts with Coatomer I coats using C-terminal dibasic motif(s) [3]

Other interactions of SCYL1

• Moreover, immunofluorescent staining indicated that NTKL and NTKL-BP1 were all localized in the cytoplasm [2].

Analytical, diagnostic and therapeutic context of SCYL1

• Here, we describe the molecular cloning and characterization of the human gene NTKL, which encodes an evolutionarily conserved kinase-like protein [1].

References