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Gene Review: 

Bhlhe22  -  basic helix-loop-helix family, member e22

Mus musculus

Synonyms: Beta3, Bhlhb5, Class B basic helix-loop-helix protein 5, Class E basic helix-loop-helix protein 22, Protein BETA3, ...
 
 
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High impact information on Bhlhb5

  • Our results reveal that a bHLH transcription factor cascade is involved in regulating retinal cell differentiation and imply that Bhlhb5 functions downstream of retinogenic factors to specify bipolar and amacrine subtypes [1].
  • Multiple amino acid sequence alignments of the Bhlhb5 family members revealed several conserved motifs and an identical 147-amino-acid carboxy-terminal region that contains a 60-amino-acid bHLH domain [2].
  • In addition Bhlhb5 is expressed in the developing eye and hair follicles, in the epithelial layer of the cochlea in the developing inner, and in the nasal epithelium [3].
  • Bhlhb5 is expressed in the CNS and sensory organs during mouse embryonic development [3].
  • Bhlhb5 is initially detected at 9.5dpc in the neural tube, restricted to longitudinal ventral columns of neurons, extending from the hindbrain to the caudal spinal cord [3].

References

  1. Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Feng, L., Xie, X., Joshi, P.S., Yang, Z., Shibasaki, K., Chow, R.L., Gan, L. Development (2006) [Pubmed]
  2. Functional and structural characterization of the human gene BHLHB5, encoding a basic helix-loop-helix transcription factor. Xu, Z.P., Dutra, A., Stellrecht, C.M., Wu, C., Piatigorsky, J., Saunders, G.F. Genomics (2002) [Pubmed]
  3. Bhlhb5 is expressed in the CNS and sensory organs during mouse embryonic development. Brunelli, S., Innocenzi, A., Cossu, G. Gene Expr. Patterns (2003) [Pubmed]
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