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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UBL5  -  ubiquitin-like 5

Homo sapiens

Synonyms: Ubiquitin-like protein 5
 
 
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High impact information on UBL5

  • Here, we report that fission yeast hub1 is an essential gene, whose loss results in cell cycle defects and inefficient pre-mRNA splicing [1].
  • Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response [2].
  • Insofar as the amino acids sequence of beacon is identical to that of ubiquitin-like 5, it is possible that the distribution of BC immunoreactivity noted in our study is that of ubiquitin-like 5 peptide in the rat hypothalamus [3].
  • Orthologs of UBL5 occur in every eukaryotic genome characterized to date [4].
  • UBL5 is a widely expressed human protein that is strongly conserved across phylogeny [4].
 

Biological context of UBL5

  • The UBL5 gene is located on chromosome 19p13.2, and its genomic structure has been examined [5].
 

Anatomical context of UBL5

  • Intracellular localization experiments in COS-7 cells showed that the recombinant UBL5 protein is cytoplasmic [5].
 

Other interactions of UBL5

  • Western analysis demonstrated that the recombinant UBL5 protein is approximately 9 kDa, as predicted from the cDNA [5].

References

  1. Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Wilkinson, C.R., Dittmar, G.A., Ohi, M.D., Uetz, P., Jones, N., Finley, D. Curr. Biol. (2004) [Pubmed]
  2. Ubiquitin-like protein 5 positively regulates chaperone gene expression in the mitochondrial unfolded protein response. Benedetti, C., Haynes, C.M., Yang, Y., Harding, H.P., Ron, D. Genetics (2006) [Pubmed]
  3. Beacon immunoreactivity in the rat hypothalamus. Ng, Y.K., Brailoiu, G.C., Dun, S.L., Ling, E.A., Yang, J., Chang, J.K., Dun, N.J. J. Neurosci. Res. (2006) [Pubmed]
  4. Structural analysis of UBL5, a novel ubiquitin-like modifier. McNally, T., Huang, Q., Janis, R.S., Liu, Z., Olejniczak, E.T., Reilly, R.M. Protein Sci. (2003) [Pubmed]
  5. Isolation of a ubiquitin-like (UBL5) gene from a screen identifying highly expressed and conserved iris genes. Friedman, J.S., Koop, B.F., Raymond, V., Walter, M.A. Genomics (2001) [Pubmed]
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