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EPB41L4A  -  erythrocyte membrane protein band 4.1 like 4A

Homo sapiens

Synonyms: Band 4.1-like protein 4A, EPB41L4, NBL4, Protein NBL4
 
 
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High impact information on EPB41L4A

  • The highest level of homology was observed with NBL4, which is a new subfamily protein of the NF2/ERM/4.1 superfamily [1].
  • Expression of hNBL4 was significantly reduced when beta-catenin was depleted in SW480 cells, a human cancer cell line that constitutionally accumulates beta-catenin [2].
  • A 2.2-kb hNBL4 transcript was expressed in all human tissues examined with high levels of expression in brain, liver, thymus and peripheral blood leukocytes and low levels of expression in heart, kidney, testis and colon [2].

References

  1. Molecular cloning of a novel NF2/ERM/4.1 superfamily gene, ehm2, that is expressed in high-metastatic K1735 murine melanoma cells. Shimizu, K., Nagamachi, Y., Tani, M., Kimura, K., Shiroishi, T., Wakana, S., Yokota, J. Genomics (2000) [Pubmed]
  2. Isolation and characterization of human NBL4, a gene involved in the beta-catenin/tcf signaling pathway. Ishiguro, H., Furukawa, Y., Daigo, Y., Miyoshi, Y., Nagasawa, Y., Nishiwaki, T., Kawasoe, T., Fujita, M., Satoh, S., Miwa, N., Fujii, Y., Nakamura, Y. Jpn. J. Cancer Res. (2000) [Pubmed]
 
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