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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ifi30  -  interferon gamma inducible protein 30

Mus musculus

Synonyms: GILT, Gamma-interferon-inducible lysosomal thiol reductase, Gamma-interferon-inducible protein IP-30, Gilt, IP30, ...
 
 
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High impact information on Ifi30

  • IP30 is an IFN-gamma-inducible 35-kDa glycoprotein that localizes in MIICs [1].
  • In the mouse forced swimming test (FST) pretreatment with a subactive dose of lithium (1 mEq/kg), given IP 45 min before the test, facilitated the antidepressant activity of iprindole, fluoxetine, and moclobemide (given IP 30 min before the test) [2].
  • In the mouse forced-swimming model, dose-dependent reversal of immobility was induced by the alpha-agonist clonidine given IP 30 min before testing [3].
  • Naltrexone hydrochloride (10 mg/kg IP 30 min before ASR testing) augmented the startle in the opioid receptor-dense HA line, but had no effect in the opioid receptor-deficient LA line, as well in the C line; therefore, the ASR magnitude in naltrexone-injected HA mice was significantly higher compared to the C line [4].
 

Analytical, diagnostic and therapeutic context of Ifi30

  • Another group of MLA350 mice received SMT 3 mg/kg IP 30 minutes before heart perfusion [5].

References

  1. Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules. Arunachalam, B., Pan, M., Cresswell, P. J. Immunol. (1998) [Pubmed]
  2. Additive effects of lithium and antidepressants in the forced swimming test: further evidence for involvement of the serotoninergic system. Nixon, M.K., Hascoet, M., Bourin, M., Colombel, M.C. Psychopharmacology (Berl.) (1994) [Pubmed]
  3. Additive effects of clonidine and antidepressant drugs in the mouse forced-swimming test. Malinge, M., Bourin, M., Colombel, M.C., Larousse, C. Psychopharmacology (Berl.) (1988) [Pubmed]
  4. Acoustic startle and open-field behavior in mice bred for magnitude of swim analgesia. Błaszczyk, J.W., Tajchert, K., Lapo, I., Sadowski, B. Physiol. Behav. (2000) [Pubmed]
  5. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: evidence from pharmacological inhibition and gene knockout mice. Xi, L., Jarrett, N.C., Hess, M.L., Kukreja, R.C. Circulation (1999) [Pubmed]
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