Disease relevance of BRDT

• In an effort to define new cancer-testis (CT) genes, we investigated whether BRDT, a testis-restricted member of the RING3 family of transcriptional regulators, is also expressed in cancer [1].
• Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9 [1].
• Standard RT-PCR expression analysis detected BRDT transcripts in 12 of 47 cases of non-small cell lung cancer and single cases of both squamous cell carcinoma of the head and neck (1/12) and esophagus (1/12) but not in melanoma or in cancers of the colon, breast, kidney and bladder [1].
• CONCLUSION: BRDT is a new, easy, and safe technique that offers a complete eradication of the tonsillar disease, short operating time, minimal intra-operative blood loss, and a suitable cost with no additional increase in postoperative pain and hemorrhage when compared to the conventional CDT [2].
• OBJECTIVES: To conduct a prospective randomized controlled study presenting and comparing bipolar radiofrequency dissection tonsillectomy (BRDT) to cold dissection tonsillectomy (CDT) regarding intra-operative blood loss, operative time, postoperative pain, and postoperative complications including hemorrhage [2].

High impact information on BRDT

• BRDT specifically binds hyperacetylated histone H4 tail depending on the integrity of both bromodomains [3].
• Moreover, in somatic cells, the ectopic expression of BRDT triggered a dramatic reorganization of the chromatin only after induction of histone hyperacetylation by trichostatin A (TSA) [3].
• Acetylation-dependent chromatin reorganization by BRDT, a testis-specific bromodomain-containing protein [3].
• The gene has been named BRDT (for bromodomain, testis specific) [4].
• In contrast, when expression of RET finger protein (RFP) and bromodomain testis-specific (BRDT) genes, which are also known to be highly expressed in the testis, was examined, no significant difference in their expression levels was observed between squamous cell carcinomas and adenocarcinomas [5].

Analytical, diagnostic and therapeutic context of BRDT

• Molecular cloning and expression of a novel alternative splice variant of BRDT gene [6].
• Our experience promotes BRDT as the preferred method of tonsillectomy [2].

References